Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition

PURPOSE: EZH2 and EZH1, the catalytic components of polycomb repressive complex 2 (PRC2), trigger trimethylation of H3K27 (H3K27me3) to repress the transcription of target genes and are implicated in the pathogenesis of various cancers including multiple myeloma and prostate cancer. Here, we investi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Rizq, Ola, Mimura, Naoya, Oshima, Motohiko, Saraya, Atsunori, Koide, Shuhei, Kato, Yuko, Aoyama, Kazumasa, Nakajima-Takagi, Yaeko, Wang, Changshan, Chiba, Tetsuhiro, Ma, Anqi, Jin, Jian, Iseki, Tohru, Nakaseko, Chiaki, Iwama, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562278/
https://ncbi.nlm.nih.gov/pubmed/28490465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2735
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados