T cells of Parkinson’s disease patients recognize α–synuclein peptides

Genetic studies associate Parkinson’s disease with alleles of the major histocompatibility complex(1–3). We find that a defined set of peptides derived from α-synuclein, a protein aggregated in Parkinson’s disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxi...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Sulzer, David, Alcalay, Roy N., Garretti, Francesca, Cote, Lucien, Kanter, Ellen, Agin-Liebes, Julian P., Liong, Christopher, McMurtrey, Curtis, Hildebrand, William H., Mao, Xiaobo, Dawson, Valina L., Dawson, Ted M., Oseroff, Carla, Pham, John, Sidney, John, Dillon, Myles B, Carpenter, Chelsea, Weiskopf, Daniela, Phillips, Elizabeth, Mallal, Simon, Peters, Bjoern, Frazier, April, Lindestam Arlehamn, Cecilia S., Sette, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626019/
https://ncbi.nlm.nih.gov/pubmed/28636593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22815
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