T cells of Parkinson’s disease patients recognize α–synuclein peptides

Genetic studies associate Parkinson’s disease with alleles of the major histocompatibility complex(1–3). We find that a defined set of peptides derived from α-synuclein, a protein aggregated in Parkinson’s disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxi...

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Gepubliceerd in:Nature
Hoofdauteurs: Sulzer, David, Alcalay, Roy N., Garretti, Francesca, Cote, Lucien, Kanter, Ellen, Agin-Liebes, Julian P., Liong, Christopher, McMurtrey, Curtis, Hildebrand, William H., Mao, Xiaobo, Dawson, Valina L., Dawson, Ted M., Oseroff, Carla, Pham, John, Sidney, John, Dillon, Myles B, Carpenter, Chelsea, Weiskopf, Daniela, Phillips, Elizabeth, Mallal, Simon, Peters, Bjoern, Frazier, April, Lindestam Arlehamn, Cecilia S., Sette, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626019/
https://ncbi.nlm.nih.gov/pubmed/28636593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22815
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