T cells of Parkinson’s disease patients recognize α–synuclein peptides

Genetic studies associate Parkinson’s disease with alleles of the major histocompatibility complex(1–3). We find that a defined set of peptides derived from α-synuclein, a protein aggregated in Parkinson’s disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxi...

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Published in:Nature
Main Authors: Sulzer, David, Alcalay, Roy N., Garretti, Francesca, Cote, Lucien, Kanter, Ellen, Agin-Liebes, Julian P., Liong, Christopher, McMurtrey, Curtis, Hildebrand, William H., Mao, Xiaobo, Dawson, Valina L., Dawson, Ted M., Oseroff, Carla, Pham, John, Sidney, John, Dillon, Myles B, Carpenter, Chelsea, Weiskopf, Daniela, Phillips, Elizabeth, Mallal, Simon, Peters, Bjoern, Frazier, April, Lindestam Arlehamn, Cecilia S., Sette, Alessandro
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626019/
https://ncbi.nlm.nih.gov/pubmed/28636593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22815
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