Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS

Mutations in autophagy genes can cause familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of autophagy in ALS pathogenesis is poorly understood, in part due to the lack of cell type-specific manipulations of this pathway in animal models. Using a mouse model of ALS expressi...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Rudnick, Noam D., Griffey, Christopher J., Guarnieri, Paolo, Gerbino, Valeria, Wang, Xueyong, Piersaint, Jason A., Tapia, Juan Carlos, Rich, Mark M., Maniatis, Tom
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625902/
https://ncbi.nlm.nih.gov/pubmed/28904095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704294114
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