Distinct roles for motor neuron autophagy early and late in the SOD1(G93A) mouse model of ALS

Mutations in autophagy genes can cause familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of autophagy in ALS pathogenesis is poorly understood, in part due to the lack of cell type-specific manipulations of this pathway in animal models. Using a mouse model of ALS expressi...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Rudnick, Noam D., Griffey, Christopher J., Guarnieri, Paolo, Gerbino, Valeria, Wang, Xueyong, Piersaint, Jason A., Tapia, Juan Carlos, Rich, Mark M., Maniatis, Tom
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625902/
https://ncbi.nlm.nih.gov/pubmed/28904095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704294114
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares