Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma

This study investigated how differences in drug distribution and free fraction at different tumor and tissue sites influence the efficacy of the multikinase inhibitor ponatinib in a patient-derived xenograft model of glioblastoma (GBM). Efficacy studies in GBM6 flank (heterotopic) and intracranial (...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Pharmacol Exp Ther
Egile Nagusiak: Laramy, Janice K., Kim, Minjee, Gupta, Shiv K., Parrish, Karen E., Zhang, Shuangling, Bakken, Katrina K., Carlson, Brett L., Mladek, Ann C., Ma, Daniel J., Sarkaria, Jann N., Elmquist, William F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2017
Gaiak:
Drug Discovery and Translational Medicine
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625285/
https://ncbi.nlm.nih.gov/pubmed/28847917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.243477
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