Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma

This study investigated how differences in drug distribution and free fraction at different tumor and tissue sites influence the efficacy of the multikinase inhibitor ponatinib in a patient-derived xenograft model of glioblastoma (GBM). Efficacy studies in GBM6 flank (heterotopic) and intracranial (...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Laramy, Janice K., Kim, Minjee, Gupta, Shiv K., Parrish, Karen E., Zhang, Shuangling, Bakken, Katrina K., Carlson, Brett L., Mladek, Ann C., Ma, Daniel J., Sarkaria, Jann N., Elmquist, William F.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2017
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625285/
https://ncbi.nlm.nih.gov/pubmed/28847917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.243477
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