Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2

Pulmonary arterial stiffness is an independent risk factor for mortality in pulmonary hypertension (PH) and plays a critical role in PH pathophysiology. Our laboratory has recently demonstrated arterial stiffening early in experimental PH, along with evidence for a mechanobiological feedback loop by...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Dieffenbach, Paul B., Haeger, Christina Mallarino, Coronata, Anna Maria F., Choi, Kyoung Moo, Varelas, Xaralabos, Tschumperlin, Daniel J., Fredenburgh, Laura E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625262/
https://ncbi.nlm.nih.gov/pubmed/28642262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00173.2017
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