T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy

HIV-specific CD8(+) T-cell responses limit viral replication in untreated infection. After the initiation of antiretroviral therapy (ART), these responses decay and the infected cell population that remains is commonly considered to be invisible to T-cells. We hypothesized that HIV antigen recogniti...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Thomas, Allison S., Jones, Kimberley L., Gandhi, Rajesh T., McMahon, Deborah K., Cyktor, Joshua C., Chan, Dora, Huang, Szu-Han, Truong, Ronald, Bosque, Alberto, Macedo, Amanda B., Kovacs, Colin, Benko, Erika, Eron, Joseph J., Bosch, Ronald J., Lalama, Christina M., Simmens, Samuel, Walker, Bruce D., Mellors, John W., Jones, R. Brad
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624641/
https://ncbi.nlm.nih.gov/pubmed/28931091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006629
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