T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy

HIV-specific CD8(+) T-cell responses limit viral replication in untreated infection. After the initiation of antiretroviral therapy (ART), these responses decay and the infected cell population that remains is commonly considered to be invisible to T-cells. We hypothesized that HIV antigen recogniti...

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Udgivet i:PLoS Pathog
Main Authors: Thomas, Allison S., Jones, Kimberley L., Gandhi, Rajesh T., McMahon, Deborah K., Cyktor, Joshua C., Chan, Dora, Huang, Szu-Han, Truong, Ronald, Bosque, Alberto, Macedo, Amanda B., Kovacs, Colin, Benko, Erika, Eron, Joseph J., Bosch, Ronald J., Lalama, Christina M., Simmens, Samuel, Walker, Bruce D., Mellors, John W., Jones, R. Brad
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624641/
https://ncbi.nlm.nih.gov/pubmed/28931091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006629
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