T cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy

OBJECTIVE. We evaluated frequencies of T cells with high PD-1 expression (PD-1(HI)) before and after long-term effective antiretroviral therapy (ART), and determined if frequencies on-ART correlated positively with measures of HIV persistence and negatively with HIV-specific responses. METHODS. We e...

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Udgivet i:AIDS
Main Authors: MACATANGAY, Bernard JC, GANDHI, Rajesh T, JONES, R Brad, MCMAHON, Deborah K, LALAMA, Christina M, BOSCH, Ronald J, CYKTOR, Joshua C, THOMAS, Allison S, BOROWSKI, Luann, RIDDLER, Sharon A, HOGG, Evelyn, STEVENSON, Eva, ERON, Joseph J, MELLORS, John W, RINALDO, Charles R
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7313719/
https://ncbi.nlm.nih.gov/pubmed/31634201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000002406
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