FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state

OBJECTIVE: (18)F-fluoromisonidazole (FMISO), a well-known PET imaging probe for diagnosis of hypoxia, is believed to accumulate in hypoxic cells via covalent binding with macromolecules after reduction of the nitro group. Previously, we showed the majority of (18)F-FMISO was incorporated into low-mo...

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Detalhes bibliográficos
Publicado no:Ann Nucl Med
Main Authors: Masaki, Yukiko, Shimizu, Yoichi, Yoshioka, Takeshi, Nishijima, Ken-ichi, Zhao, Songji, Higashino, Kenichi, Numata, Yoshito, Tamaki, Nagara, Kuge, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Japan 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622914/
https://ncbi.nlm.nih.gov/pubmed/28695498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12149-017-1189-9
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