The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites

(18)F-fluoromisonidazole (FMISO) has been widely used as a hypoxia imaging probe for diagnostic positron emission tomography (PET). FMISO is believed to accumulate in hypoxic cells via covalent binding with macromolecules after reduction of its nitro group. However, its detailed accumulation mechani...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Masaki, Yukiko, Shimizu, Yoichi, Yoshioka, Takeshi, Tanaka, Yukari, Nishijima, Ken-ichi, Zhao, Songji, Higashino, Kenichi, Sakamoto, Shingo, Numata, Yoshito, Yamaguchi, Yoshitaka, Tamaki, Nagara, Kuge, Yuji
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652161/
https://ncbi.nlm.nih.gov/pubmed/26582591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16802
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