Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice

Obesity was reported to cause kidney injury by excessive accumulation of sphingolipids such as sphingomyelin and ceramide. Sphingomyelin synthase 2 (SMS2) is an important enzyme for hepatic sphingolipid homeostasis and its dysfunction is considered to result in fatty liver disease. The expression of...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sugimoto, Masayuki, Wakabayashi, Masato, Shimizu, Yoichi, Yoshioka, Takeshi, Higashino, Kenichi, Numata, Yoshito, Okuda, Tomohiko, Zhao, Songji, Sakai, Shota, Igarashi, Yasuyuki, Kuge, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806983/
https://ncbi.nlm.nih.gov/pubmed/27010944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152191
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