The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites

(18)F-fluoromisonidazole (FMISO) has been widely used as a hypoxia imaging probe for diagnostic positron emission tomography (PET). FMISO is believed to accumulate in hypoxic cells via covalent binding with macromolecules after reduction of its nitro group. However, its detailed accumulation mechani...

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Publicado en:Sci Rep
Main Authors: Masaki, Yukiko, Shimizu, Yoichi, Yoshioka, Takeshi, Tanaka, Yukari, Nishijima, Ken-ichi, Zhao, Songji, Higashino, Kenichi, Sakamoto, Shingo, Numata, Yoshito, Yamaguchi, Yoshitaka, Tamaki, Nagara, Kuge, Yuji
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652161/
https://ncbi.nlm.nih.gov/pubmed/26582591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16802
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