The pan-BCL-2-blocker obatoclax (GX15-070) and the PI3-kinase/mTOR-inhibitor BEZ235 produce cooperative growth-inhibitory effects in ALL cells

Acute lymphoblastic leukemia (ALL) is characterized by leukemic expansion of lymphoid blasts in hematopoietic tissues. Despite improved therapy only a subset of patients can be cured. Therefore, current research is focusing on new drug-targets. Members of the BCL-2 family and components of the PI3-k...

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Pubblicato in:Oncotarget
Autori principali: Stefanzl, Gabriele, Berger, Daniela, Cerny-Reiterer, Sabine, Blatt, Katharina, Eisenwort, Gregor, Sperr, Wolfgang R., Hoermann, Gregor, Lind, Karin, Hauswirth, Alexander W., Bettelheim, Peter, Sill, Heinz, Melo, Junia V., Jäger, Ulrich, Valent, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620205/
https://ncbi.nlm.nih.gov/pubmed/28978065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18810
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