Tumor antigen glycosaminoglycan modification regulates antibody-drug conjugate delivery and cytotoxicity

Aggressive cancers are characterized by hypoxia, which is a key driver of tumor development and treatment resistance. Proteins specifically expressed in the hypoxic tumor microenvironment thus represent interesting candidates for targeted drug delivery strategies. Carbonic anhydrase (CAIX) has been...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Christianson, Helena C., Menard, Julien A., Indira Chandran, Vineesh, Bourseau-Guilmain, Erika, Shevela, Dmitry, Lidfeldt, Jon, Månsson, Ann-Sofie, Pastorekova, Silvia, Messinger, Johannes, Belting, Mattias
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620149/
https://ncbi.nlm.nih.gov/pubmed/28978009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16921
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