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Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Hypoxia, or low oxygen tension, is a major regulator of tumor development and aggressiveness. However, how cancer cells adapt to hypoxia and communicate with their surrounding microenvironment during tumor development remain important questions. Here, we show that secreted vesicles with exosome char...

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Detalhes bibliográficos
Main Authors: Kucharzewska, Paulina, Christianson, Helena C., Welch, Johanna E., Svensson, Katrin J., Fredlund, Erik, Ringnér, Markus, Mörgelin, Matthias, Bourseau-Guilmain, Erika, Bengzon, Johan, Belting, Mattias
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645587/
https://ncbi.nlm.nih.gov/pubmed/23589885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220998110
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