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Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Hypoxia, or low oxygen tension, is a major regulator of tumor development and aggressiveness. However, how cancer cells adapt to hypoxia and communicate with their surrounding microenvironment during tumor development remain important questions. Here, we show that secreted vesicles with exosome char...

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Bibliografiske detaljer
Main Authors: Kucharzewska, Paulina, Christianson, Helena C., Welch, Johanna E., Svensson, Katrin J., Fredlund, Erik, Ringnér, Markus, Mörgelin, Matthias, Bourseau-Guilmain, Erika, Bengzon, Johan, Belting, Mattias
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645587/
https://ncbi.nlm.nih.gov/pubmed/23589885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220998110
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