Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

The role of exosomes in cancer can be inferred from the observation that they transfer tumor cell derived genetic material and signaling proteins, resulting in e.g. increased tumor angiogenesis and metastasis. However, the membrane transport mechanisms and the signaling events involved in the uptake...

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Detalhes bibliográficos
Main Authors: Svensson, Katrin J., Christianson, Helena C., Wittrup, Anders, Bourseau-Guilmain, Erika, Lindqvist, Eva, Svensson, Lena M., Mörgelin, Matthias, Belting, Mattias
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682571/
https://ncbi.nlm.nih.gov/pubmed/23653359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445403
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