β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment

A number of xenobiotic-inducible cytochrome P450s (CYPs) are now known to be localized in the mitochondrial compartment, though their pharmacological or toxicological roles remain unclear. Here, we show that BNF treatment markedly inhibits liver mitochondrial O(2) consumption rate (OCR), ADP-depende...

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Vydáno v:Oxid Med Cell Longev
Hlavní autoři: Anandasadagopan, Suresh Kumar, Singh, Naveen M., Raza, Haider, Bansal, Seema, Selvaraj, Venkatesh, Singh, Shilpee, Chowdhury, Anindya Roy, Leu, Nicolae Adrian, Avadhani, Narayan G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618780/
https://ncbi.nlm.nih.gov/pubmed/29098061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5213186
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