Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and Its Role in Polycyclic Aromatic Hydrocarbon-induced Mitochondrial Dysfunction

We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Site-directed mutagenesis, COS-7 cell transfection, and in vitro impor...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bansal, Seema, Leu, Adrian N., Gonzalez, Frank J., Guengerich, F. Peter, Chowdhury, Anindya Roy, Anandatheerthavarada, Hindupur K., Avadhani, Narayan G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Metabolism
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975038/
https://ncbi.nlm.nih.gov/pubmed/24497629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.525659
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