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Identification of Genetic Variants of Human Cytochrome P450 2D6 with Impaired Mitochondrial Targeting
Human cytochrome P450 2D6 (CYP2D6) is responsible for the metabolism of approximately 20% of drugs in common clinical use. The CYP2D6 gene locus is highly polymorphic. Many of the polymorphisms have been shown to be clinically relevant and can account for inter-individual differences in the metaboli...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794965/ https://ncbi.nlm.nih.gov/pubmed/19781968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2009.08.009 |
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