Human Liver Mitochondrial Cytochrome P450 2D6: Individual Variations and Implications in Drug Metabolism

Constitutively expressed human cytochrome P450 2D6 (CYP2D6) is responsible for the metabolism of approximately 25% of drugs in common clinical use. It is widely accepted that CYP2D6 is localized in the endoplasmic reticulum of cells; however, we have identified this enzyme in the mitochondria of hum...

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Main Authors: Cook Sangar, Michelle L., Anandatheerthavarada, Hindupur K., Tang, Weigang, Prabu, Subbuswamy K., Martin, Martha V., Dostalek, Miroslav, Guengerich, F. Peter, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789264/
https://ncbi.nlm.nih.gov/pubmed/19438707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07067.x
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