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Human Liver Mitochondrial Cytochrome P450 2D6: Individual Variations and Implications in Drug Metabolism
Constitutively expressed human cytochrome P450 2D6 (CYP2D6) is responsible for the metabolism of approximately 25% of drugs in common clinical use. It is widely accepted that CYP2D6 is localized in the endoplasmic reticulum of cells; however, we have identified this enzyme in the mitochondria of hum...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2789264/ https://ncbi.nlm.nih.gov/pubmed/19438707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07067.x |
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