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Human Cytochrome P450 2E1 Mutations That Alter Mitochondrial Targeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models

Human polymorphisms in the 5′-upstream regulatory regions and also protein coding regions of cytochrome P450 2E1 (CYP2E1) are known to be associated with several diseases, including cancer and alcohol liver toxicity. In this study, we report novel mutations in the N-terminal protein targeting region...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Bansal, Seema, Anandatheerthavarada, Hindupur K., Prabu, Govindaswamy K., Milne, Ginger L., Martin, Martha V., Guengerich, F. Peter, Avadhani, Narayan G.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642310/
https://ncbi.nlm.nih.gov/pubmed/23471973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.452367
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