Human Cytochrome P450 2E1 Mutations That Alter Mitochondrial Targeting Efficiency and Susceptibility to Ethanol-induced Toxicity in Cellular Models

Human polymorphisms in the 5′-upstream regulatory regions and also protein coding regions of cytochrome P450 2E1 (CYP2E1) are known to be associated with several diseases, including cancer and alcohol liver toxicity. In this study, we report novel mutations in the N-terminal protein targeting region...

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Main Authors: Bansal, Seema, Anandatheerthavarada, Hindupur K., Prabu, Govindaswamy K., Milne, Ginger L., Martin, Martha V., Guengerich, F. Peter, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Bioenergetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642310/
https://ncbi.nlm.nih.gov/pubmed/23471973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.452367
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