Mitochondria-targeted Cytochrome P450 2E1 Induces Oxidative Damage and Augments Alcohol-mediated Oxidative Stress

The ethanol-inducible cytochrome P450 2E1 (CYP2E1) is also induced under different pathological and physiological conditions. Studies including ours have shown that CYP2E1 is bimodally targeted to both the endoplasmic reticulum (microsomes) (mc CYP2E1) and mitochondria (mt CYP2E1). In this study we...

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Détails bibliographiques
Auteurs principaux: Bansal, Seema, Liu, Chuan-Peng, Sepuri, Naresh B. V., Anandatheerthavarada, Hindupur K., Selvaraj, Venkatesh, Hoek, Jan, Milne, Ginger L., Guengerich, F. Peter, Avadhani, Narayan G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Membrane Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915697/
https://ncbi.nlm.nih.gov/pubmed/20529841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121822
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