Additive Effects of Mitochondrion-targeted Cytochrome CYP2E1 and Alcohol Toxicity on Cytochrome c Oxidase Function and Stability of Respirosome Complexes

Alcohol treatment induces oxidative stress by a combination of increased production of partially reduced oxygen species and decreased cellular antioxidant pool, including GSH. Recently, we showed that mitochondrion-targeted CYP2E1 augments alcohol-mediated toxicity, causing an increase in reactive o...

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Detalhes bibliográficos
Main Authors: Bansal, Seema, Srinivasan, Satish, Anandasadagopan, Sureshkumar, Roy Chowdhury, Anindya, Selvaraj, Venkatesh, Kalyanaraman, Balaraman, Joseph, Joy, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346148/
https://ncbi.nlm.nih.gov/pubmed/22396533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314062
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