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β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment

A number of xenobiotic-inducible cytochrome P450s (CYPs) are now known to be localized in the mitochondrial compartment, though their pharmacological or toxicological roles remain unclear. Here, we show that BNF treatment markedly inhibits liver mitochondrial O(2) consumption rate (OCR), ADP-depende...

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Detalles Bibliográficos
Publicado en:Oxid Med Cell Longev
Main Authors: Anandasadagopan, Suresh Kumar, Singh, Naveen M., Raza, Haider, Bansal, Seema, Selvaraj, Venkatesh, Singh, Shilpee, Chowdhury, Anindya Roy, Leu, Nicolae Adrian, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618780/
https://ncbi.nlm.nih.gov/pubmed/29098061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5213186
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