β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment

A number of xenobiotic-inducible cytochrome P450s (CYPs) are now known to be localized in the mitochondrial compartment, though their pharmacological or toxicological roles remain unclear. Here, we show that BNF treatment markedly inhibits liver mitochondrial O(2) consumption rate (OCR), ADP-depende...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Anandasadagopan, Suresh Kumar, Singh, Naveen M., Raza, Haider, Bansal, Seema, Selvaraj, Venkatesh, Singh, Shilpee, Chowdhury, Anindya Roy, Leu, Nicolae Adrian, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618780/
https://ncbi.nlm.nih.gov/pubmed/29098061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5213186
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