Cigarette Smoke Toxins-Induced Mitochondrial Dysfunction and Pancreatitis Involves Aryl Hydrocarbon Receptor Mediated Cyp1 Gene Expression: Protective Effects of Resveratrol

We previously reported that mitochondrial CYP1 enzymes participate in the metabolism of polycyclic aromatic hydrocarbons and other carcinogens leading to mitochondrial dysfunction. In this study, using Cyp1b1(−)(/)(−), Cyp1a1/1a2(−)(/)(−), and Cyp1a1/1a2/1b1(−)(/)(−) mice, we observed that cigarette...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Ghosh, Jyotirmoy, Chowdhury, Anindya Roy, Srinivasan, Satish, Chattopadhyay, Mrittika, Bose, Moumita, Bhattacharya, Sabyasachi, Raza, Haider, Fuchs, Serge Y, Rustgi, Anil K, Gonzalez, Frank J, Avadhani, Narayan G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
AHR-Mediated Effects of Cigarette Smoke
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260170/
https://ncbi.nlm.nih.gov/pubmed/30165701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy206
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