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Force and affinity in ligand discrimination by the TCR

T cell recognition of antigen is a physical process that requires formation of a cell-cell junction that is rich in active force generation. Recently, a biomolecular force probe was used to examine how the TCR-pMHC interaction responds to force and the consequences of force dependent interactions fo...

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Detalhes bibliográficos
Publicado no:Trends Immunol
Main Authors: Depoil, David, Dustin, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617748/
https://ncbi.nlm.nih.gov/pubmed/25466309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2014.10.007
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