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Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity

Ebolavirus (EBOV), an enveloped filamentous RNA virus causing severe hemorrhagic fever, enters cells by macropinocytosis and membrane fusion in a late endosomal compartment. Fusion is mediated by the EBOV envelope glycoprotein GP, which consists of subunits GP1 and GP2. GP1 binds to cellular recepto...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Lee, Jinwoo, Nyenhuis, David A., Nelson, Elizabeth A., Cafiso, David S., White, Judith M., Tamm, Lukas K.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617291/
https://ncbi.nlm.nih.gov/pubmed/28874543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708052114
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