Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry

Cholesterol serves critical roles in enveloped virus fusion by modulating membrane properties. The glycoprotein (GP) of Ebola virus (EBOV) promotes fusion in the endosome, a process that requires the endosomal cholesterol transporter NPC1. However, the role of cholesterol in EBOV fusion is unclear....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Struct Mol Biol
Päätekijät: Lee, Jinwoo, Kreutzberger, Alex J. B., Odongo, Laura, Nelson, Elizabeth A., Nyenhuis, David A., Kiessling, Volker, Liang, Binyong, Cafiso, David S., White, Judith M., Tamm, Lukas K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992113/
https://ncbi.nlm.nih.gov/pubmed/33462517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00548-4
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