The Roles of Histidines and Charged Residues as Potential Triggers of a Conformational Change in the Fusion Loop of Ebola Virus Glycoprotein

Ebola virus (EBOV) enters cells from late endosomes/lysosomes under mildly acidic conditions. Entry by fusion with the endosomal membrane requires the fusion loop (FL, residues 507–560) of the EBOV surface glycoprotein to undergo a pH-dependent conformational change. To find the pH trigger for this...

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Udgivet i:PLoS One
Main Authors: Lee, Jinwoo, Gregory, Sonia M., Nelson, Elizabeth A., White, Judith M., Tamm, Lukas K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811418/
https://ncbi.nlm.nih.gov/pubmed/27023721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152527
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