Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT(1)), its associated G protein, and β-arrestins are...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Suofu, Yalikun, Li, Wei, Jean-Alphonse, Frédéric G., Jia, Jiaoying, Khattar, Nicolas K., Li, Jiatong, Baranov, Sergei V., Leronni, Daniela, Mihalik, Amanda C., He, Yanqing, Cecon, Erika, Wehbi, Vanessa L., Kim, JinHo, Heath, Brianna E., Baranova, Oxana V., Wang, Xiaomin, Gable, Matthew J., Kretz, Eric S., Di Benedetto, Giulietta, Lezon, Timothy R., Ferrando, Lisa M., Larkin, Timothy M., Sullivan, Mara, Yablonska, Svitlana, Wang, Jingjing, Minnigh, M. Beth, Guillaumet, Gérald, Suzenet, Franck, Richardson, R. Mark, Poloyac, Samuel M., Stolz, Donna B., Jockers, Ralf, Witt-Enderby, Paula A., Carlisle, Diane L., Vilardaga, Jean-Pierre, Friedlander, Robert M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617277/
https://ncbi.nlm.nih.gov/pubmed/28874589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705768114
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