Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT(1)), its associated G protein, and β-arrestins are...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Suofu, Yalikun, Li, Wei, Jean-Alphonse, Frédéric G., Jia, Jiaoying, Khattar, Nicolas K., Li, Jiatong, Baranov, Sergei V., Leronni, Daniela, Mihalik, Amanda C., He, Yanqing, Cecon, Erika, Wehbi, Vanessa L., Kim, JinHo, Heath, Brianna E., Baranova, Oxana V., Wang, Xiaomin, Gable, Matthew J., Kretz, Eric S., Di Benedetto, Giulietta, Lezon, Timothy R., Ferrando, Lisa M., Larkin, Timothy M., Sullivan, Mara, Yablonska, Svitlana, Wang, Jingjing, Minnigh, M. Beth, Guillaumet, Gérald, Suzenet, Franck, Richardson, R. Mark, Poloyac, Samuel M., Stolz, Donna B., Jockers, Ralf, Witt-Enderby, Paula A., Carlisle, Diane L., Vilardaga, Jean-Pierre, Friedlander, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617277/
https://ncbi.nlm.nih.gov/pubmed/28874589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705768114
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