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Design and validation of the first cell‐impermeant melatonin receptor agonist
BACKGROUND AND PURPOSE: The paradigm that GPCRs are able to prolong or initiate cellular signalling through intracellular receptors recently emerged. Melatonin binds to G protein‐coupled MT(1) and MT(2) receptors. In contrast to most other hormones targeting GPCRs, melatonin and its synthetic analog...
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| Опубликовано в: : | Br J Pharmacol |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley and Sons Inc.
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5481653/ https://ncbi.nlm.nih.gov/pubmed/28493341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13856 |
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