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Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions

Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61, GPR62 and GPR135 among the melatonin recepto...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Oishi, Atsuro, Karamitri, Angeliki, Gerbier, Romain, Lahuna, Olivier, Ahmad, Raise, Jockers, Ralf
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566548/
https://ncbi.nlm.nih.gov/pubmed/28827538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08996-7
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