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Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions

Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61, GPR62 and GPR135 among the melatonin recepto...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Oishi, Atsuro, Karamitri, Angeliki, Gerbier, Romain, Lahuna, Olivier, Ahmad, Raise, Jockers, Ralf
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566548/
https://ncbi.nlm.nih.gov/pubmed/28827538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08996-7
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