The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

Transforming growth factor-β (TGFβ) signaling is initiated by the type I, II TGFβ receptor (TβRI/TβRII) complex. Here we report the formation of an alternative complex between TβRI and the orphan GPR50, belonging to the G protein-coupled receptor super-family. The interaction of GPR50 with TβRI indu...

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Udgivet i:Nat Commun
Main Authors: Wojciech, Stefanie, Ahmad, Raise, Belaid-Choucair, Zakia, Journé, Anne-Sophie, Gallet, Sarah, Dam, Julie, Daulat, Avais, Ndiaye-Lobry, Delphine, Lahuna, Olivier, Karamitri, Angeliki, Guillaume, Jean-Luc, Do Cruzeiro, Marcio, Guillonneau, François, Saade, Anastasia, Clément, Nathalie, Courivaud, Thomas, Kaabi, Nawel, Tadagaki, Kenjiro, Delagrange, Philippe, Prévot, Vincent, Hermine, Olivier, Prunier, Céline, Jockers, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865211/
https://ncbi.nlm.nih.gov/pubmed/29572483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03609-x
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