Importance of the second extracellular loop for melatonin MT(1) receptor function and absence of melatonin binding in GPR50

BACKGROUND AND PURPOSE: Recent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand binding and gating and receptor activation. Here, we have assessed the role of the E2 loop in the activation of the melatonin MT(1) receptor an...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Clement, Nathalie, Renault, Nicolas, Guillaume, Jean‐Luc, Cecon, Erika, Journé, Anne‐Sophie, Laurent, Xavier, Tadagaki, Kenjiro, Cogé, Francis, Gohier, Arnaud, Delagrange, Philippe, Chavatte, Philippe, Jockers, Ralf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Themed Section: Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057912/
https://ncbi.nlm.nih.gov/pubmed/28898928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14029
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