Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions

Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61, GPR62 and GPR135 among the melatonin recepto...

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Vydáno v:Sci Rep
Hlavní autoři: Oishi, Atsuro, Karamitri, Angeliki, Gerbier, Romain, Lahuna, Olivier, Ahmad, Raise, Jockers, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566548/
https://ncbi.nlm.nih.gov/pubmed/28827538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08996-7
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