Design and validation of the first cell‐impermeant melatonin receptor agonist

BACKGROUND AND PURPOSE: The paradigm that GPCRs are able to prolong or initiate cellular signalling through intracellular receptors recently emerged. Melatonin binds to G protein‐coupled MT(1) and MT(2) receptors. In contrast to most other hormones targeting GPCRs, melatonin and its synthetic analog...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Gbahou, Florence, Cecon, Erika, Viault, Guillaume, Gerbier, Romain, Jean‐Alphonse, Frederic, Karamitri, Angeliki, Guillaumet, Gérald, Delagrange, Philippe, Friedlander, Robert M, Vilardaga, Jean‐Pierre, Suzenet, Franck, Jockers, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481653/
https://ncbi.nlm.nih.gov/pubmed/28493341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13856
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