Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Chronic inflammation is a pathologic feature of neurodegeneration and aging; however, the mechanism regulating this process is not understood. Melatonin, an endogenous free radical scavenger synthesized by neuronal mitochondria, decreases with aging and neurodegeneration. We proposed that insufficie...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Jauhari, Abhishek, Baranov, Sergei V., Suofu, Yalikun, Kim, Jinho, Singh, Tanisha, Yablonska, Svitlana, Li, Fang, Wang, Xiaomin, Oberly, Patrick, Minnigh, M. Beth, Poloyac, Samuel M., Carlisle, Diane L., Friedlander, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260019/
https://ncbi.nlm.nih.gov/pubmed/32182222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135026
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