Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors

Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment. Furthermore, most in vitro experiments to select resistance to dolut...

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Publicado en:mBio
Autores principales: Malet, Isabelle, Subra, Frédéric, Charpentier, Charlotte, Collin, Gilles, Descamps, Diane, Calvez, Vincent, Marcelin, Anne-Geneviève, Delelis, Olivier
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615196/
https://ncbi.nlm.nih.gov/pubmed/28951475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00922-17
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