Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

T-lineage committed precursor thymocytes are screened by a fate-determination process mediated via T cell receptor (TCR) signals for differentiation into distinct lineages. However, it remains unclear whether any antecedent event is required to couple TCR signals with the transcriptional program gov...

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發表在:Nat Commun
Main Authors: Kojo, Satoshi, Tanaka, Hirokazu, Endo, Takaho A., Muroi, Sawako, Liu, Ye, Seo, Wooseok, Tenno, Mari, Kakugawa, Kiyokazu, Naoe, Yoshinori, Nair, Krutula, Moro, Kazuyo, Katsuragi, Yoshinori, Kanai, Akinori, Inaba, Toshiya, Egawa, Takeshi, Venkatesh, Byrappa, Minoda, Aki, Kominami, Ryo, Taniuchi, Ichiro
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615048/
https://ncbi.nlm.nih.gov/pubmed/28951542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00768-1
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