Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus

CD4(+) helper and CD8(+) cytotoxic T cells differentiate from common precursors in the thymus after T-cell receptor (TCR)-mediated selection. Commitment to the helper lineage depends on persistent TCR signals and expression of the ThPOK transcription factor, whereas a ThPOK cis-regulatory element, T...

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Bibliografiske detaljer
Main Authors: Tanaka, Hirokazu, Naito, Taku, Muroi, Sawako, Seo, Wooseok, Chihara, Risa, Miyamoto, Chizuko, Kominami, Ryo, Taniuchi, Ichiro
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630353/
https://ncbi.nlm.nih.gov/pubmed/23481257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.47
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