Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

The Rho GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3 complex-mediated actin polymerization, which underpins diverse cellular processes. Here we report the structure of a WRC-Rac1 complex determined by cryo-electron microscopy. Surprisingly, Rac1 is not located at the bindi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Chen, Baoyu, Chou, Hui-Ting, Brautigam, Chad A, Xing, Wenmin, Yang, Sheng, Henry, Lisa, Doolittle, Lynda K, Walz, Thomas, Rosen, Michael K
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2017
Gaiak:
Structural Biology and Molecular Biophysics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614565/
https://ncbi.nlm.nih.gov/pubmed/28949297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29795
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak