Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

The Rho GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3 complex-mediated actin polymerization, which underpins diverse cellular processes. Here we report the structure of a WRC-Rac1 complex determined by cryo-electron microscopy. Surprisingly, Rac1 is not located at the bindi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Chen, Baoyu, Chou, Hui-Ting, Brautigam, Chad A, Xing, Wenmin, Yang, Sheng, Henry, Lisa, Doolittle, Lynda K, Walz, Thomas, Rosen, Michael K
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614565/
https://ncbi.nlm.nih.gov/pubmed/28949297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29795
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