ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin

EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains poorly explored. Here we report that the zinc-finger protein ZNF516 is a transcription repres...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Li, Lifang, Liu, Xinhua, He, Lin, Yang, Jianguo, Pei, Fei, Li, Wanjin, Liu, Shumeng, Chen, Zhe, Xie, Guojia, Xu, Bosen, Ting, Xia, Zhang, Zihan, Jin, Tong, Liu, Xujun, Zhang, Wenting, Yuan, Shuai, Yang, Ziran, Wu, Chongyang, Zhang, Yu, Yang, Xiaohan, Yi, Xia, Liang, Jing, Shang, Yongfeng, Sun, Luyang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612949/
https://ncbi.nlm.nih.gov/pubmed/28947780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00702-5
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