Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly

The de novo assembly and post-splicing reassembly of the U4/U6.U5 tri-snRNP remain to be investigated. We report here that ZIP, a protein containing a CCCH-type zinc finger and a G-patch domain, as characterized by us previously, regulates pre-mRNA splicing independent of RNA binding. We found that...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Chen, Zhe, Gui, Bin, Zhang, Yu, Xie, Guojia, Li, Wanjin, Liu, Shumeng, Xu, Bosen, Wu, Chongyang, He, Lin, Yang, Jianguo, Yi, Xia, Yang, Xiaohan, Sun, Luyang, Liang, Jing, Shang, Yongfeng
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672036/
https://ncbi.nlm.nih.gov/pubmed/28878014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.797357
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